These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Dry HCl in parallel synthesis of fused pyrimidin-4-ones.
    Author: Bogolubsky AV, Ryabukhin SV, Plaskon AS, Stetsenko SV, Volochnyuk DM, Tolmachev AA.
    Journal: J Comb Chem; 2008; 10(6):858-62. PubMed ID: 18767818.
    Abstract:
    The parallel solution-phase synthesis of substituted thieno[2,3- d]pyrimidin-6-carboxylic acids has been accomplished. This strategy relies on a cyclization of 2-aminothiophen-3,5-dicarboxylates with a set of nitriles, followed by hydrolysis to construct the library of corresponding acids. The convenient procedure for use and dosage of dry HCl for the reaction was elaborated and adapted for semiautomated solution-phase parallel synthesis. With the use of another (hetero)aromatic ortho-aminocarboxylate, mini-libraries of diverse fused pyrimidin-4-ones were synthesized. The scope and limitations of the approach are discussed.
    [Abstract] [Full Text] [Related] [New Search]