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  • Title: Nongenomic effect of aldosterone on ion transport pathways of red blood cells.
    Author: Ivanova L, Bernhardt R, Bernhardt I.
    Journal: Cell Physiol Biochem; 2008; 22(1-4):269-78. PubMed ID: 18769054.
    Abstract:
    The direct influence of aldosterone on the human and avian red blood cell (RBC) transport systems, Na(+)/K(+) pump, Na(+),K(+),2Cl(-) symporter, and K(+) (Na(+))/H(+) exchanger, was investigated with tracer kinetics. The present work proved that aldosterone has no significant effect on these transport pathways. However, in young human RBCs containing reticulocytes aldosterone showed a significant inhibition of the Na(+),K(+),2Cl(-) symporter. Investigations of the Li(+) efflux via the Na(+)/Li(+) exchanger using atom absorption spectroscopy revealed that aldosterone has no effect on this transporter. Studies of the effect of aldosterone on the Ca(2+) content and the intracellular pH (pH(i)) were carried out on single RBCs with a fluorescence imaging system. Both parameters are affected by aldosterone. The Ca(2+) uptake in the presence of aldosterone, under conditions where the Ca(2+) pump is inhibited, showed marked differences from the control. Since the effect is nifedipine-sensitive, it seems that aldosterone affects a Ca(2+) channel. In addition, aldosterone leads to an acidification of the intracellular medium after an initial alkalisation due to an effect on the Na(+)/H(+) exchanger.
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