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  • Title: Hypothermic protection following middle cerebral artery occlusion in the rat.
    Author: Baker CJ, Onesti ST, Barth KN, Prestigiacomo CJ, Solomon RA.
    Journal: Surg Neurol; 1991 Sep; 36(3):175-80. PubMed ID: 1876967.
    Abstract:
    The effects of deep hypothermia on ischemic neuronal injury were examined using a permanent middle cerebral artery occlusion model in the rat. Animals were maintained at temporalis temperatures of either 24 degrees C or 36 degrees C and killed 6 hours after arterial occlusion. Normothermic rats displayed an average infarct volume of 25.1% +/- 1.6% of the right hemisphere, whereas hypothermic rats had an average infarct volume of 4.1% +/- 1.3% (p less than 0.001). The right/left hemispheric ratio was 1.05 +/- 0.02 in the normothermic group and 1.00 +/- 0.02 in the hypothermic group (p less than 0.05). These results suggest that hypothermia to 24 degrees C may reduce cerebral infarction and edema formation following middle cerebral artery occlusion in the rat.
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