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  • Title: [Isotretinoin embryopathy. Report of one case].
    Author: Troncoso Sch M, Rojas H C, Bravo C E.
    Journal: Rev Med Chil; 2008 Jun; 136(6):763-6. PubMed ID: 18769834.
    Abstract:
    Retinoic acid is a widely used drug in the treatment of cystic acne. It has teratogenic effects that depend on the gestational period in which it is used. We report a seven months old female whose mother was exposed to retinoic acid in both pre-gestational and gestational periods. She had a retardation of psychomotor development and a brain MRI showed frontal atrophy and a malformation of the posterior fossa. We discuss the mechanisms of the teratogenic effects of retinoic acid.
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