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  • Title: Iron-catalyzed cross-coupling reactions between a bicyclic alkenyl triflate and Grignard reagents.
    Author: Le Marquand P, Tsui GC, Whitney JC, Tam W.
    Journal: J Org Chem; 2008 Oct 03; 73(19):7829-32. PubMed ID: 18771327.
    Abstract:
    Fe-catalyzed cross-coupling reactions between a bicyclic alkenyl triflate and Grignard reagents were investigated. Under the optimized reaction conditions, various 2-substituted bicyclic alkenes were synthesized in moderate to excellent yields (52-93%). This method provided an efficient route for the synthesis of 2-substituted bicyclic alkenes with secondary alkyl groups which cannot be synthesized using previous methods such as Pd-catalyzed coupling reactions and lithium-halide exchange reactions.
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