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  • Title: Sleep symptoms and their clinical correlates in Machado-Joseph disease.
    Author: D'Abreu A, França M, Conz L, Friedman JH, Nucci AM, Cendes F, Lopes-Cendes I.
    Journal: Acta Neurol Scand; 2009 Apr; 119(4):277-80. PubMed ID: 18771522.
    Abstract:
    OBJECTIVE: To evaluate the presence of sleep symptoms in Machado-Joseph disease/spinocerebellar ataxia type 3 (MJD/SCA3). SUBJECTS/METHODS: We used a sleep questionnaire and the Epworth Sleepiness Scale to compare 53 patients with MJD/SCA3 and 106 controls. RESULTS: Patients with MJD/SCA3 reported more symptoms of insomnia, restless leg syndrome and REM sleep behavior disorder as well as nocturnal cramps, snoring and nocturnal apnea. Insomnia was the most frequently reported sleep-related complaint in the MJD/SCA3 group. CONCLUSIONS: Our results indicate that sleep disorders are common in patients with MJD/SCA3 and probably have a multifactorial etiology, with components of a primary sleep disorder in addition to sleep-disrupting symptoms such as nocturia and cramps.
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