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  • Title: K(ATP)-channels and glucose-regulated glucagon secretion.
    Author: Rorsman P, Salehi SA, Abdulkader F, Braun M, MacDonald PE.
    Journal: Trends Endocrinol Metab; 2008 Oct; 19(8):277-84. PubMed ID: 18771934.
    Abstract:
    Glucagon, secreted by the alpha-cells of the pancreatic islets, is the most important glucose-increasing hormone of the body. The precise regulation of glucagon release remains incompletely defined but has been proposed to involve release of inhibitory factors from neighbouring beta-cells (paracrine control). However, the observation that glucose can regulate glucagon secretion under conditions when insulin secretion does not occur argues that the alpha-cell is also equipped with its own intrinsic (exerted within the alpha-cell itself) glucose sensing. Here we consider the possible mechanisms involved with a focus on ATP-regulated K(+)-channels and changes in alpha-cell membrane potential.
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