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  • Title: Serotonin-dopamine interaction in the induction and maintenance of L-DOPA-induced dyskinesias.
    Author: Carta M, Carlsson T, Muñoz A, Kirik D, Björklund A.
    Journal: Prog Brain Res; 2008; 172():465-78. PubMed ID: 18772046.
    Abstract:
    Appearance of dyskinesia is a common problem of long-term Levodopa (L-DOPA) treatment in Parkinson's disease (PD) patients and represents a major limitation for the pharmacological management of the motor symptoms in the advanced stages of disease. An increasing body of evidence points to dopamine released as a false neurotransmitter from the striatal serotonin terminals as the main pre-synaptic determinant of L-DOPA-induced dyskinesia. Here we review the animal experimental and human clinical data in support of this view, which point to the serotonin system as a promising target for anti-dyskinetic therapy in PD patients under L-DOPA medication.
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