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  • Title: Neuroleptic malignant syndrome without fever after addition of oxcarbazepine to long-term treatment with amisulpride.
    Author: Angelopoulos P, Markopoulou M, Kyamidis K, Bobotas K.
    Journal: Gen Hosp Psychiatry; 2008; 30(5):482-4. PubMed ID: 18774435.
    Abstract:
    OBJECTIVE: Our goal was to report a case of malignant neuroleptic syndrome in a patient administered with both oxcarbazepine (OXCBZ) and amisulpride (AM). METHOD: We present a case of a young man who presented with symptoms of malignant neuroleptic syndrome after progressive titration of OXCBZ (1,200 mg) added to the long-term treatment with AM (800 mg). RESULTS: After discontinuation of AM and administration of dopaminergic drugs, his clinical symptoms improved gradually. CONCLUSION: This case suggests that clinicians should consider the risk of neuroleptic malignant syndrome when OXCBZ is coadministered to patients undergoing long-term treatment with neuroleptics.
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