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  • Title: Frajunolides E-K, briarane diterpenes from Junceella fragilis.
    Author: Liaw CC, Shen YC, Lin YS, Hwang TL, Kuo YH, Khalil AT.
    Journal: J Nat Prod; 2008 Sep; 71(9):1551-6. PubMed ID: 18774864.
    Abstract:
    Chemical investigation of the gorgonian octocoral Junceella fragilis, collected in Taiwan, resulted in the isolation of seven new briarane-type diterpenes, frajunolides E-K (1-7), in addition to 14 known briaranes, praelolide, junceellin, junceellolides A-E, and K, 11a,20a-epoxy-4-deacetoxyjunceelolide D, umbraculolide A, junceellonoid A, and juncins Y, Z, and ZI, as well as ergosterol peroxide. The structures of 1-7 were determined by analysis of HRESIMS and 2D NMR spectroscopic data. Cytotoxicity and in vitro anti-inflammatory activities of compounds 1-7 were also evaluated.
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