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  • Title: Role of B cells in systemic lupus erythematosus and rheumatoid arthritis.
    Author: Mandik-Nayak L, Ridge N, Fields M, Park AY, Erikson J.
    Journal: Curr Opin Immunol; 2008 Dec; 20(6):639-45. PubMed ID: 18775493.
    Abstract:
    B cell tolerance to many self-proteins is actively maintained by either purging self-reactive B receptors through clonal deletion and receptor editing, or by functional silencing known as anergy. However, these processes are clearly incomplete as B cell driven autoimmune diseases still occur. The significance of B cells in two such diseases, rheumatoid arthritis and systemic lupus erythematosus, is highlighted by the ameliorative effects of B cell depletion. It remains to be determined, however, whether the key role of the B cell in autoimmune disease is autoantibody production or another antibody-independent function.
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