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  • Title: Anandamide effects on 5-HT(3) receptors in vivo.
    Author: Rácz I, Bilkei-Gorzo A, Markert A, Stamer F, Göthert M, Zimmer A.
    Journal: Eur J Pharmacol; 2008 Oct 31; 596(1-3):98-101. PubMed ID: 18775693.
    Abstract:
    Studies in knockout mouse strains have shown that some cannabimimetic effects persist in animals lacking cannabinoid CB(1) and CB(2) receptors. These residual effects are thought to result, in part, from a cannabinoid-modulation of ion channels. This study investigates the role of 5-HT(3) receptors as a potential in vivo target for cannabinoids. Mice deficient in CB(1) and CB(2) receptors were treated with Delta(9)-tetrahydrocannabinol and anandamide, in the presence of the 5-HT(3) antagonist ondansetron. We show that the cannabinoid receptor-independent anandamide analgesia, but not catalepsy, is completely blocked by ondansetron. Thus, 5-HT(3) receptors seem to be involved in cannabinoid analgesia.
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