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  • Title: Distribution of microcystins in various organs (heart, liver, intestine, gonad, brain, kidney and lung) of Wistar rat via intravenous injection.
    Author: Wang Q, Xie P, Chen J, Liang G.
    Journal: Toxicon; 2008 Nov; 52(6):721-7. PubMed ID: 18775740.
    Abstract:
    The distribution of microcystins (MCs) in various tissues of Wistar rats was studied under laboratory conditions. Rats were injected intravenously (i.v.) with extracted MCs at a dose of 80 microg MC-LR(equivalent)/kg body weight. MCs concentrations in various tissues were detected at 1, 2, 4, 6, 12 and 24h post-injection using liquid chromatography-mass spectrometry (LC-MS). The highest concentration of MCs was found in kidney (0.034-0.295 microg/g dry weight), followed by lung (0.007-0.067 microg/g dry weight), stomach (0.010-0.058 microg/g dry weight) and liver (0.003-0.052 microg/g dry weight). The maximum MCs content in the whole body of rat, 2.9% of the injected dose, was observed at 2h post-injection. MCs concentration was higher in kidney than in liver during the experiment, and two peaks of MCs concentration (at 2 and 24h, respectively) were observed in kidney, indicating that MCs can be excreted directly via kidney of rat. Though heart, intestine, spleen, brain, gonad and stomach contained less than 0.2% of injected MCs during the whole experiment stage, the presence of MCs in these tissues represents potential damage to them.
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