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  • Title: New platinum(II) complexes targeting the loops of the human telomeric G-quadruplex.
    Author: Bertrand H, Bombard S, Monchaud D, Teulade-Fichou MP.
    Journal: Nucleic Acids Symp Ser (Oxf); 2008; (52):163-4. PubMed ID: 18776304.
    Abstract:
    Two novel series of platinum(II) complexes have been designed and shown to interact with the human telomeric G-quadruplex-DNA via different binding modes: i- terpyridine-platinum (Pt-tpy) complexes covalently interact with quadruplex-DNA via selective platination of adenine residues of the loops, their interaction being driven by the aromatic surface of the ligand; ii- platinum-quinacridine hybrid (Pt-MPQ) interacts with quadruplex-DNA via a dual noncovalent/covalent binding mode, targeting preferentially guanines constitutive of external G-quartets. Therefore, platinum complexes presented herein constitute potential agents for irreversible trapping of G-quadruplex.DNA.
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