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  • Title: Base-modified ribonucleosides as potential anti-hepatitis C virus agents.
    Author: Ivanov AV, Smirnova OA, Golubeva NA, Ivanov MA, Tunitskaya VL, Shipitsyn AV, Alexandrova LA.
    Journal: Nucleic Acids Symp Ser (Oxf); 2008; (52):619-20. PubMed ID: 18776532.
    Abstract:
    Four novel series of base modified ribonucleoside analogues were synthesized and evaluated as potential anti-HCV agents. For two compounds notable anti-HCV activity was observed The triphosphates of bicyclic pyrimidine ribonucleosides were studied as substrates/inhibitors of HCV RNA-dependent RNA polymerase (RdRp, NS5B protein) and RNA helicase/NTPase (NS3 protein).
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