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  • Title: Nucleoside phosphonic acids in thymidine phosphorylase inhibition: structure-activity relationship.
    Author: Panova N, Kosiová I, Petrová M, Vanĕk V, Liboska R, Kovacková S, Kocalka P, Králíková S, Tocík Z, Páv O, Paces O, Rejman D, Rosenberg I.
    Journal: Nucleic Acids Symp Ser (Oxf); 2008; (52):665-6. PubMed ID: 18776555.
    Abstract:
    A number of structurally diverse nucleoside phosphonic acids have been tested against human recombinant thymidine phosphorylase and human platelets supernatant using 2'-deoxy-5-nitrouridine as the substrate. We have selected several inhibitors working at micromolar level as lead structures for further evaluation.
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