These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Ketoprofen spray-dried microspheres based on Eudragit RS and RL: study of the manufacturing parameters.
    Author: Rassu G, Gavini E, Spada G, Giunchedi P, Marceddu S.
    Journal: Drug Dev Ind Pharm; 2008 Nov; 34(11):1178-87. PubMed ID: 18777240.
    Abstract:
    The preparation of ketoprofen spray-dried microspheres can be affected by the long drug recrystallization time. Polymer type and drug-polymer ratio as well as manufacturing parameters affect the preparation. The purpose of this work was to evaluate the possibility to obtain ketoprofen spray-dried microspheres using the Eudragit RS and RL; the influence of the spray-drying parameters on morphology, dimension, and physical stability of microspheres was studied. Ketoprofen microspheres based on Eudragit blend can be prepared by spray-drying and the nebulization parameters do not influence significantly particle properties; nevertheless, they can be affected by drying and storage methods. No effect of the container material is found.
    [Abstract] [Full Text] [Related] [New Search]