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  • Title: [Effect of low molecular weight regulators on the biosynthesis of rifamycin B by Amycolatopsis mediterranei strains].
    Author: Bushueva OA, Efremenkova OV, Gorin SE, Bartoshevich IuE.
    Journal: Antibiot Khimioter; 1991 Mar; 36(3):11-5. PubMed ID: 1877868.
    Abstract:
    Formation of differentiation regulators of the A-factor group in representatives of Nocardia and Nocardia-like actinomyces: N. asteroides, N. brasiliensis, Amycolatopsis mediterranei and "Streptomyces listeri" was observed. The effect of the regulators of different nature (barbital, A-factor and B-factor) on biosynthesis of rifamycin B by A. mediterranei strains was studied. It was shown that the A-factor stimulated rifamycin B production in the adifferentiated low active variant isolated from a natural population of the active strain VNIIA 1713 of the rifamycin B-producing culture. B-Factor insignificantly inhibited biosynthesis of rifamycin B in the studied strains of A. mediterranei.
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