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  • Title: Cultured bovine endothelial cells convert big endothelin isopeptides to mature endothelin isopeptides.
    Author: Ohnaka K, Takayanagi R, Yamauchi T, Umeda F, Nawata H.
    Journal: Biochem Int; 1991 Feb; 23(3):499-506. PubMed ID: 1877988.
    Abstract:
    The incubation of big endothelin-1 (big ET-1), big ET-2 or big ET-3 with cultured bovine endothelial cells (ECs) resulted in their conversions to mature endothelins (ETs). These conversions apparently exhibited Michaelis-Menten kinetics as a function of each big ET isopeptide. The conversions of big ETs were abolished by phosphoramidon. These results indicate that vascular endothelium can convert exogenous big ET-1 to mature ET-1 through a phosphoramidon-sensitive metalloprotease, and that this enzyme has also high affinities for big ET-2 and big ET-3.
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