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  • Title: [Selection of antipsychotic drugs in a psychiatric hospital based on the results of CATIE study].
    Author: Gutiérrez-Suela F.
    Journal: Farm Hosp; 2008; 32(2):83-90. PubMed ID: 18783707.
    Abstract:
    OBJECTIVE: To choose typical or atypical antipsychotic drugs for treatment of schizophrenic patients in a psychiatric hospital. METHOD: A standard method was used; this method considers four main evaluation criteria and four secondary criteria. The typical antipsychotic drug, perphenazine, was compared with the atypical antipsychotic drugs (olanzapine, quetiapine, risperidone and ziprasidone). The measures of efficacy of the most important criteria come from the clinical trial Clinical Antipsychotic Trials for Intervention Effectiveness (CATIE). RESULTS: The scores of the different antipsychotic drugs were as follows: perphenazine, 59.68; olanzapine, 52.98; risperidone, 51.53; ziprasidone, 46.42 and quetiapine, 45.41. Olanzapine was equal to perphenazine when the cost criteria was reduced by 72.97%. CONCLUSIONS: The typical antipsychotic drug perphenazine is the drug receiving the best assessment for the treatment of schizophrenia. Olanzapine is an alternative if its cost is reduced.
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