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  • Title: Chiral separation of fluvastatin enantiomers by capillary electrophoresis.
    Author: Trung TQ, Dung PT, Hoan NN, Kim DJ, Lee JH, Kim KH.
    Journal: Arch Pharm Res; 2008 Aug; 31(8):1066-72. PubMed ID: 18787799.
    Abstract:
    An analytical CE method was developed for the enantiomeric purity determination of fluvastatin enantiomers. Fluvastatin enantiomers were separated on an uncoated fused silica with 100 mM-borate solution containing 30 mg/mL of (2-hydroxypropyl)-beta-cyclodextrin (HP-beta-CD) as running buffer and fenoprofen as an internal standard. The linearity was observed within a 400-700 microg/mL concentration range (r(2)>or=0.995) for both fluvastatin enantiomers. The repeatability expressed as coefficient of variation (CV) of the method were 0.96 and 0.92% for (+)-3R, 5S and (-)-3S, 5R-fluvastatin, respectively. The limit of detection and quantification for both fluvastatin enantiomers were 1.5 microg/mL and 2.5 microg/mL, respectively.
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