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  • Title: Dedifferentiated chondrosarcoma arising from osteochondromatosis. A case report.
    Author: Du YK, Shih HN, Wang JM, Shih CH.
    Journal: Changgeng Yi Xue Za Zhi; 1991 Jun; 14(2):130-5. PubMed ID: 1878807.
    Abstract:
    Multiple hereditary osteochondromata has a higher incidence (5%-25%) of malignant change into chondrosarcoma than solitary osteochondroma (1%-2%); but only less than 10% of all chondrosarcomas may undergo dedifferentiated change into fibrosarcoma or malignant fibrous histiocytoma. We have a case presented here with osteochondromatosis who was found to have dedifferentiated chondrosarcoma arising from pelvic osteochondroma. Radical extra-compartmental resection was done and followed by chemotherapy and radiotherapy. Recurrence was found 3 months later. Early recognition of malignant change and adequate surgical resection with adjuvant therapy may prevent local recurrence and increase the survival rate.
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