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  • Title: Gamma-lactones alpha,beta- and beta,gamma-fused to carbocycles as novel antiproliferative drugs.
    Author: León LG, Machín RP, Rodríguez CM, Ravelo JL, Martín VS, Padrón JM.
    Journal: Bioorg Med Chem Lett; 2008 Oct 01; 18(19):5171-3. PubMed ID: 18789684.
    Abstract:
    A set of gamma-lactones alpha,beta-fused and beta,gamma-fused to carbocycles have been synthesized and evaluated for their in vitro antiproliferative activities using the human cancer cell lines SW1573 (lung), T-47D (breast) and WiDr (colon). The compounds are obtained by intramolecular ring closing metathesis of the corresponding dienes. Active compounds exhibited GI(50) values in the range 8-18 microM. A structure-activity relationship is also discussed.
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