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  • Title: Synthesis and immunological evaluation of self-adjuvanting glycolipopeptide vaccine candidates.
    Author: Fujita Y, Abdel-Aal AB, Wimmer N, Batzloff MR, Good MF, Toth I.
    Journal: Bioorg Med Chem; 2008 Oct 01; 16(19):8907-13. PubMed ID: 18789866.
    Abstract:
    Synthesis of four glycolipids with different number of lauroyl groups on glucose or cellobiose as scaffolds is described. Their immunological evaluations either admixed with or covalently linked to J8, a peptide antigen derived from the C-terminus of the antiphagocytic M-protein of group A streptococcus, are also investigated. Administration of mixtures of J8 and glycolipids to B10BR (H-2(k)) mice induced low-levels of J8-specific IgG antibodies. While glycolipopeptides, in which J8 was covalently linked to the synthetic glycolipids, demonstrated high-levels of antibody titers comparable with the co-administration of these glycolipopeptides with complete Freund's adjuvant, suggesting clearly the strong potency of the synthesized glycolipids as self-adjuvanting moieties.
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