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  • Title: Severe eosinophilia as a manifestation of acute graft-versus-host disease.
    Author: Paralkar VR, Goradia A, Luger SM, Loren AW.
    Journal: Oncology; 2008; 75(3-4):134-6. PubMed ID: 18791329.
    Abstract:
    Significant peripheral eosinophilia in association with acute graft-versus-host disease (GVHD) is rare. Here we report a case of eosinophilia in a 30-year-old woman with relapsed acute myelogenous leukemia after an allogeneic bone marrow transplant who was treated with donor lymphocyte infusion (DLI). A month after the DLI, she developed a pruritic erythematous rash, hepatic enzyme elevations and eosinophilia that peaked at 23,300 cells/mm(3). A diagnosis of acute GVHD was made and the patient was treated with corticosteroids with a resolution of all of the aforementioned findings. The authors suggest that eosinophilia in a bone marrow transplantation patient should raise suspicion of GVHD.
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