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  • Title: Using the blocks database to recognize functional domains.
    Author: Henikoff JG, Greene EA, Taylor N, Henikoff S, Pietrokovski S.
    Journal: Curr Protoc Bioinformatics; 2002 Aug; Chapter 2():Unit 2.2. PubMed ID: 18792933.
    Abstract:
    Blocks are ungapped multiple alignments of related protein sequence segments that correspond to the most conserved regions of the proteins. The Blocks Database is a collection of blocks representing known protein families that can be used to compare a protein or DNA sequence with documented families of proteins. Protocols in this unit describe the analysis of proteins and families using Blocks-based tools, including searching, exploring relationships with trees, making new blocks, and designing PCR primers from blocks for isolating homologous sequences.
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