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  • Title: Role of IGF-1 in glucose regulation and cardiovascular disease.
    Author: Abbas A, Grant PJ, Kearney MT.
    Journal: Expert Rev Cardiovasc Ther; 2008 Sep; 6(8):1135-49. PubMed ID: 18793116.
    Abstract:
    IGF-1 is a peptide hormone that is expressed in most tissues. It shares significant structural and functional similarities with insulin, and is implicated in the pathogenesis of insulin resistance and cardiovascular disease. Recombinant human IGF-1 has been used in Type 2 diabetes to improve insulin sensitivity and aid glycemic control. There is evidence supporting IGF-1 as a vascular protective factor and it may also be beneficial in the treatment of chronic heart failure. Further understanding of the effects of IGF-1 signaling in health and disease may lead to novel approaches to the prevention and treatment of diabetes and cardiovascular disease.
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