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  • Title: The effects of estramustine on metaphase and anaphase in DU 145 prostatic carcinoma cells.
    Author: Sheridan VR, Speicher LA, Tew KD.
    Journal: Eur J Cell Biol; 1991 Apr; 54(2):268-76. PubMed ID: 1879438.
    Abstract:
    The chemotherapeutic drug, estramustine, has been shown to cause the disassembly of microtubules via binding to microtubule-associated proteins. In this report, estramustine is shown to be a potent inhibitor of mitotic progression in the human prostatic carcinoma cell line, DU 145. Examination of individual living cells via video-enhanced differential interference contrast (DIC) optics shows that the drug delays the onset of anaphase, reduces anaphase spindle-pole elongation (anaphase B), and delays cytokinesis. In addition, immunofluorescent studies demonstrate that estramustine causes a rapid disorganization of the mitotic apparatus at significantly lower concentrations than those reported previously. Electron microscopic studies show that microtubule bundles are present in drug-treated mitotic cells in association with kinetochores and centrioles.
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