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  • Title: Normalization of 14-3-3 in CJD.
    Author: Schrooten M, De Vooght W, Weckhuysen S, Van Paesschen W, Van Damme P.
    Journal: Acta Neurol Belg; 2008 Jun; 108(2):64-6. PubMed ID: 18795599.
    Abstract:
    We report on a 47-year-old woman with autopsy proven Creutzfeldt-Jakob disease (CJD), who had a positive initial 14-3-3 test but a subsequent negative test under pharmacologic suppression of the periodic epileptiform discharges on EEG. Multiple factors associated with a subsequent 14-3-3 test becoming negative are known. However none of these circumstances were applicable to our patient. This case history suggests sedative therapy in CJD may induce false negative 14-3-3 testing. This appears to be a relevant finding, since the differential diagnosis between non-convulsive status epilepticus and CJD is not always evident in the initial stage of the disease and some patients with CJD present with seizures.
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