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  • Title: A 13-year-old girl with cold agglutinin syndrome caused by anti-i.
    Author: Mason HM, Arndt PA.
    Journal: J Pediatr Hematol Oncol; 2008 Jul; 30(7):543-5. PubMed ID: 18797203.
    Abstract:
    A 13-year-old girl with cold agglutinin syndrome caused by anti-i was serologically positive for Epstein-Barr virus. The anti-i had a high titer at 4 degrees C and high thermal amplitude (reacting up to 37 degrees C with both cord i RBCs and the patient's autologous RBCs). The patient's hemoglobin dropped to 48 g/L. The age of the patient, the severity of the hemolysis, and the antibody specificity were unusual features of cold agglutinin syndrome. Transfusions with adult (I) red blood cells were effective.
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