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  • Title: Delayed inhibition creates amplitude tuning of mouse inferior collicular neurons.
    Author: Tang J, Xiao ZJ, Shen JX.
    Journal: Neuroreport; 2008 Oct 08; 19(15):1445-9. PubMed ID: 18797295.
    Abstract:
    Nonmonotonic intensity response neurons referred as amplitude-tuned neurons are considered to be created by high-threshold inhibition in auditory system. Very limited information, however, is available on how the inhibition works for amplitude-tuned neurons. We studied the temporal response properties of these neurons with or without iontophoresis of bicuculline (gamma-aminobutyric acid A antagonist). In most neurons, the firing durations gradually reduced with the increasing amplitudes beyond the best amplitudes. Bicuculline application selectively blocked the inhibition of the sustained responses to high amplitudes and abolished the nonmonotonic intensity response properties. Our results suggest that a temporally delayed inhibition, whose latency reduced related to excitation with the increasing amplitude, is responsible for the creation of about 71% amplitude-tuned neurons in mouse inferior colliculus.
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