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  • Title: [Loss of differentiation of a prostate adenocarcinoma after hormone therapy: the example of a metastasis in the spongy body of the penis].
    Author: Uphoff J, Woziwodzki J, Schattka SO, Kollias A.
    Journal: Aktuelle Urol; 2008 Sep; 39(5):373-7. PubMed ID: 18798127.
    Abstract:
    Penile metastases are very uncommon. Prostate cancer as the most frequent malignoma of the male is the main primary lesion. Metastases in the penis only occur at an advanced state of the tumour and with a high dedifferentiation, e. g., ductal adenocarcinoma. Changes in the morphology of the prostate carcinoma are specially known for the occurrence of small-cell neuroendocrine and undifferentiated carcinomas. Often prior to the transformation an anti-androgen therapy has been undertaken. At this state of the disease, there is only the possibility of a palliative therapy with a poor prognosis. The increasing histological dedifferentiation of the tumour tissue can make it difficult or even impossible to identify the primary lesion.
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