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  • Title: Carbamazepine-induced drug-induced hypersensitivity syndrome in a 14-year-old Japanese boy.
    Author: Suzuki Y, Fukuda M, Tohyama M, Ishikawa M, Yasukawa M, Ishii E.
    Journal: Epilepsia; 2008 Dec; 49(12):2118-21. PubMed ID: 18801036.
    Abstract:
    Drug-induced hypersensitivity syndrome (DIHS) is a life-threatening idiosyncratic drug reaction, and an early accurate diagnosis is essential for its treatment. We describe a 14-year-old boy with localization-related epilepsy, who developed severe adverse cutaneous and systemic reactions after 3 weeks of carbamazepine administration. During the course of the clinical symptoms, reactivation of human herpesvirus 6 (HHV-6) was proven by detection of the HHV-6 genome in serum and elevation of HHV-6 immunoglobulin G (IgG). He fulfilled the newly established criteria for DIHS. Among eight identified medications that can precipitate DIHS, four are antiepileptic drugs. Establishing a treatment strategy for DIHS is warranted to improve its outcome. Therefore, it is important to raise awareness of DIHS among epileptologists.
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