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  • Title: G alpha14 is a candidate mediator of sweet/umami signal transduction in the posterior region of the mouse tongue.
    Author: Shindo Y, Miura H, Carninci P, Kawai J, Hayashizaki Y, Ninomiya Y, Hino A, Kanda T, Kusakabe Y.
    Journal: Biochem Biophys Res Commun; 2008 Nov 21; 376(3):504-8. PubMed ID: 18801333.
    Abstract:
    Gustducin, a G alpha subunit expressed in taste cells, is known as a key molecule for sweet, umami and bitter taste signal transduction. However, previous studies demonstrated that the contribution of gustducin to the sweet/umami responses in the posterior region of the tongue is less than that in the anterior region, implying the existence of another G alpha subunit mediating sweet/umami taste signal transduction. Here, we propose G alpha14, a member of G alpha q family, as the candidate mediator. G alpha14 was found in our subtracted full-length cDNA library derived from mouse circumvallate papillae (CV) and expressed in a subset of taste cells in CV and foliate papillae, but not in fungiform papillae and soft palate. G alpha14 was co-expressed with T1r3, a sweet/umami taste receptor, but not with gustducin in CV. These results suggest the important roles of G alpha14 in sweet/umami taste signal transduction in the posterior region of the tongue.
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