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  • Title: Association of MMP-3 5A/6A gene polymorphism with susceptibility to carotid atherosclerosis.
    Author: Djurić T, Zivković M, Radak D, Jekić D, Radak S, Stojković L, Raicević R, Stanković A, Alavantić D.
    Journal: Clin Biochem; 2008 Nov; 41(16-17):1326-9. PubMed ID: 18801353.
    Abstract:
    OBJECTIVES: Stromelysin-1 (MMP-3) as a key member of metalloproteinase family could have an important role in atherogenesis. The 5A/6A polymorphism in the promoter of MMP-3 gene affects the level of MMP-3 gene expression. We assessed whether the MMP-3 promoter low- and high-activity genotypes are related to susceptibility for carotid atherosclerosis (CA) in Serbian population. DESIGN AND METHODS: The study group of case-control design consisted of 515 participants. The 265 patients with ultrasonographic evidence of carotid plaque presence were recruited for the study. The 5A/6A polymorphism was typed by RFLP-PCR. RESULTS: There was significantly higher prevalence of genotypes containing 6A allele in the patients with CA compared to controls (p<0.05). The model of inheritance with the dominant effect of 6A allele gave elevated and significant OR for carotid atherosclerosis (adjusted OR 2.35, CI=1.0-5.5, p=0.048). CONCLUSIONS: Subjects carrying genotypes with 6A allele had significantly higher susceptibility to carotid atherosclerosis.
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