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  • Title: Experimental approaches for solution X-ray scattering and fiber diffraction.
    Author: Tsuruta H, Irving TC.
    Journal: Curr Opin Struct Biol; 2008 Oct; 18(5):601-8. PubMed ID: 18801437.
    Abstract:
    X-ray scattering and diffraction from non-crystalline systems have gained renewed interest in recent years, as focus shifts from the structural chemistry information gained by high-resolution studies to the context of structural physiology at larger length scales. Such techniques permit the study of isolated macromolecules as well as highly organized macromolecular assemblies as a whole under near-physiological conditions. Time-resolved approaches, made possible by advanced synchrotron instrumentation, add a crucial dimension to many of these investigations. This article reviews experimental approaches in non-crystalline X-ray scattering and diffraction that may be used to illuminate important scientific questions such as protein/nucleic acid folding and structure-function relationships in large macromolecular assemblies.
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