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  • Title: Recent developments in microwave-assisted protein chemistries - can this be integrated into the drug discovery and validation process?
    Author: Sandoval WN, Pham VC, Lill JR.
    Journal: Drug Discov Today; 2008 Dec; 13(23-24):1075-81. PubMed ID: 18801456.
    Abstract:
    Over the past 30 years, biotechnology has evolved as a multibillion dollar industry. A large sector of this industry is associated with translating human genetic information to discover, develop and commercialize bio-therapeutics. A broad range of disciplines across the Life Sciences is necessary for the selection of bio-molecules as biotechnological drug targets. Global and targeted proteomic approaches, as well as in-depth characterization of select proteins, are part of the process necessary for drug discovery and validation. Recently, microwave-assisted proteomic methodologies have emerged as useful tools for increasing the bio-catalysis and, therefore, throughput of analytical processes associated with protein characterization. Several microwave-assisted protocols that have become integrated into the drug discovery research process in the biotechnology industry are discussed.
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