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  • Title: Studies on inhibition mechanism of transcription factor NF-kappaB and DNA binding by chelator pyrogallol red on the basis of its interaction with metal ions.
    Author: Sharma RK, Chelladurai C, Tiwari AD, Rajor HK, Mehta S, Otsuka M.
    Journal: Bioorg Med Chem; 2008 Oct 01; 16(19):9018-22. PubMed ID: 18801661.
    Abstract:
    Recent studies have shown that the zinc influences the DNA binding of transcription factor NF-kappaB. So the zinc-interaction of pyrogallol red (PR) an inhibitor of NF-kappaB-DNA binding was studied by isolating the zinc-PR complex. The complex was characterized using IR, UV-visible, 1H NMR, and thermal studies. Binding sites of PR were investigated by molecular modeling using MM+ and PM3 methods and by generating molecular electrostatic map. These studies have confirmed the role of metal ion chelation in the inhibition of NF-kappaB-DNA binding by PR.
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