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  • Title: The unusual binding abilities of the His-analogue of Arg-vasopressin towards Cu2+.
    Author: Brasuń J, Cebrat M, Sochacka A, Gładysz O, Swiatek-Kozłowska J.
    Journal: Dalton Trans; 2008 Oct 07; (37):4978-80. PubMed ID: 18802608.
    Abstract:
    A new vasopressin analogue, [His1,6]AVP, was synthesized and characterized by potentiometric measurements as well as by UV-Vis, CD and EPR spectroscopy. At the physiological pH the peptide forms a stable complex with Cu2+ ions which is characterized by the {NH2, NIm, NIm(macrochelate)} binding mode. The replacement of both Cys by His residues in the vasopressin sequence results in a very significant increase in the efficiency of Cu2+ binding.
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