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  • Title: Amine and ammonium functionalization of chloromethylsilane-ended dendrimers. Antimicrobial activity studies.
    Author: Ortega P, Copa-Patiño JL, Muñoz-Fernandez MA, Soliveri J, Gomez R, de la Mata FJ.
    Journal: Org Biomol Chem; 2008 Sep 21; 6(18):3264-9. PubMed ID: 18802631.
    Abstract:
    Novel amine- and ammonium-terminated carbosilane dendrimers of type G(n)-[Si{CH(2)O-(C(6)H(4))-3-NMe(2)}](x) or G(n)-[Si{CH(2)O-(C(6)H(4))-3-NMe(3)(+)I(-)}](x) have been synthesized and characterized up to second generation by phenolysis of (chloromethyl)silyl-terminated dendrimers with 3-dimethylamine phenol and subsequent quaternization with methyl iodide. Quaternized carbosilane dendrimers are stable in protic solvents and can be solubilised in water after the addition of less than 1% of dimethyl sulfoxide. A study of the antimicrobial activity of these cationic dendrimers of first and second generation against both gram-positive and gram-negative bacteria is also described. The results obtained demonstrate that the new ammonium-terminated carbosilane dendrimers can be considered as multivalent biocides.
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