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  • Title: A prospective randomized controlled trial of preimplantation genetic screening in the "good prognosis" patient.
    Author: Meyer LR, Klipstein S, Hazlett WD, Nasta T, Mangan P, Karande VC.
    Journal: Fertil Steril; 2009 May; 91(5):1731-8. PubMed ID: 18804207.
    Abstract:
    OBJECTIVE: To determine whether the routine use of preimplantation genetic screening (PGS) in "good prognosis" women improves in vitro fertilization (IVF) cycle outcome. DESIGN: Randomized, controlled, prospective clinical study. SETTING: Private infertility clinic. PATIENT(S): Infertile women predicted to have a good prognosis as defined by: age <39 years, normal ovarian reserve, body mass index <30 kg/m(2), presence of ejaculated sperm, normal uterus, <or=2 previous failed IVF cycles. INTERVENTION(S): Patients were randomized to the PGS group or the control group on day 3 after oocyte retrieval; 23 women underwent blastomere biopsy on day 3 after fertilization (PGS group), and 24 women underwent routine IVF (control group). All embryos were transferred on day 5 or 6 after fertilization. MAIN OUTCOME MEASURE(S): Pregnancy, implantation, multiple gestation, and live birth rates. RESULT(S): No statistically significant differences were found between the PGS and control groups with respect to clinical pregnancy rate (52.4% versus 72.7%). However, the embryo implantation rate was statistically significantly lower for the PGS group (31.7% versus 62.3%) as were the live birth rate (28.6% versus 68.2%) and the multiple birth rate (9.1% versus 46.7%). CONCLUSION(S): In a "good prognosis" population of women, PGS does not appear to improve pregnancy, implantation, or live birth rates.
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