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  • Title: [Propionic acid fermentation by Propionibacterium freudenreichii CCTCC M207015 with a fibrous-bed bioreactor].
    Author: Feng X, Wu B, Shen X, Xu H.
    Journal: Sheng Wu Gong Cheng Xue Bao; 2008 Jun; 24(6):1075-9. PubMed ID: 18807995.
    Abstract:
    The production of propionic acid by Propionibacterium freudenreichii CCTCC M207015 was investigated in a Fibrous-bed bioreactor (FBB). The FBB was constructed by packing spiral cotton fibrous and immobilized into a bioreactor. By applying this bioreactor to propionic acid fermentation, the propionic acid yield had a significant improvement and reached 20.41 g/L, compared with the cell-free culture of 14.58 g/L (40 g/L of glucose). At the same time, the glucose exhausting time decreased from 120 h to 60 h. Batch fermentations at various glucose concentrations were carried out with FBB. Based on the analysis of the time course of production, fed-batch fermentation was also applied to produce propionic acid with FBB, the maximal propionic acid yield reached 45.91 g/L, and the proportion of propionic acid to total acids was about 72.31%.
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