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  • Title: Facile preparation of alpha-aryl nitriles by direct cyanation of alcohols with TMSCN under the catalysis of InX3.
    Author: Chen G, Wang Z, Wu J, Ding K.
    Journal: Org Lett; 2008 Oct 16; 10(20):4573-6. PubMed ID: 18808133.
    Abstract:
    A convenient and efficient synthesis of alpha-aryl nitriles was developed by direct cyanation of alcohols with TMSCN under the catalysis of Lewis acid. Using 5-10 mol % of InBr3 as the catalyst, a variety of benzylic alcohols can be converted to the corresponding nitriles in 5-30 min with yields of 46-99%.
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