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Title: Tet 42, a novel tetracycline resistance determinant isolated from deep terrestrial subsurface bacteria. Author: Brown MG, Mitchell EH, Balkwill DL. Journal: Antimicrob Agents Chemother; 2008 Dec; 52(12):4518-21. PubMed ID: 18809935. Abstract: Tet 42, a novel tetracycline resistance determinant from deep subsurface bacteria, was characterized and found to have a 30% sequence similarity to TetA(Z). The protein is a putative efflux pump that shares characteristics with previously characterized pumps, including a divergently transcribed TetR repressor, a conserved GxxSDRxGRR motif, and transmembrane domains.[Abstract] [Full Text] [Related] [New Search]