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  • Title: Globus pallidus alterations and brain atrophy in liver cirrhosis patients with encephalopathy: an MR imaging study.
    Author: Zeneroli ML, Cioni G, Crisi G, Vezzelli C, Ventura E.
    Journal: Magn Reson Imaging; 1991; 9(3):295-302. PubMed ID: 1881246.
    Abstract:
    Brain magnetic resonance (MR) was performed in 29 liver cirrhosis patients without (N = 10) and with hepatic encephalopathy (HE) of chronic recurrent (N = 10) and of chronic persistent (N = 9) type. Sixty percent of the patients with chronic recurrent HE and 100% of the patients with chronic persistent HE showed a bilateral and symmetrical hyperintensity of the globus pallidus in the T1-weighted images while the T2-weighted images were normal, suggesting the possibility of the accumulation of a paramagnetic compound in this brain area during HE. Other findings of the study were evidence of brain atrophy of mild or moderate degree in 70% of patients with chronic recurrent HE and in 77% with chronic persistent HE and patients with liver cirrhosis without HE appeared normal on MR examination.
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