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  • Title: Biodegradable nanogels prepared by self-assembly of poly(L-lactide)-grafted dextran: entrapment and release of proteins.
    Author: Nagahama K, Ouchi T, Ohya Y.
    Journal: Macromol Biosci; 2008 Nov 10; 8(11):1044-52. PubMed ID: 18814318.
    Abstract:
    We showed previously that poly(L-lactide)-grafted dextran could form biodegradable nanogels in water. In this paper, various properties of Dex-g-PLLA nanogels were compared with Dex-Chol (dextran-cholesterol conjugate) nanogels to investigate the effects of hydrophobic units. Dex-g-PLLA nanogels exhibited significantly lower CAC and higher colloidal stability, indicating a strong tendency to form nanogels. We prepared lysozyme-loaded Dex-g-PLLA nanogels, and they exhibited a sustained release of lysozyme for 1 week without denaturation in PBS at 37 degrees C. The Dex-g-PLLA nanogels therefore have great potential as a delivery vehicle for therapeutic protein.
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