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  • Title: Synthesis and SAR study of T-type calcium channel blockers. Part II.
    Author: Choe YJ, Seo HN, Jung SY, Rhim H, Kim J, Choo DJ, Lee JY.
    Journal: Arch Pharm (Weinheim); 2008 Oct; 341(10):661-4. PubMed ID: 18816587.
    Abstract:
    3,4-Dihydroquinazoline derivatives have been known to be the novel and potent T-type calcium channel blockers. From a systematic variation of 3,4-dihydroquinazoline derivative 5c (KYS05043), plausible SAR results were established. It was revealed that a 5-(dimethylamino)pentylamino group at R(1), a biphenyl group at R(2), and a benzyl amido group at R(3)in the 3,4-dihydroquinazoline backbone are closely related with the channel selectivity (T/N-type) as well as the potency based on the discovery of 6k (KYS05090).
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