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  • Title: 2-sulfonyliminodihydropyrimidines: a novel class of analgesic compounds.
    Author: González-Rosende ME, Olivar T, Castillo E, Sepúlveda-Arques J.
    Journal: Arch Pharm (Weinheim); 2008 Nov; 341(11):690-5. PubMed ID: 18816588.
    Abstract:
    A series of 2-sulfonyliminodihydropyrimidine derivatives have been synthesized and evaluated in vivo for their antinociceptive and anti-inflammatory activities. The results were compared with that of acetyl salicylic acid. Compounds 6Ab-d and 6Be displayed an interesting analgesic profile in the acetic acid-induced abdominal contractions test. Based on the results of the carrageenan-hind paw edema test, compound 6Af showed potential anti-inflammatory activity.
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