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  • Title: [Change in the level of vasoactive intestinal peptide in the cerebral cortex and hypothalamus and behavioral reactions of rats after frontal lobectomy].
    Author: Karganov MIu, Romanova GA, Goriacheva TV, Kadar T, Telegdi D.
    Journal: Patol Fiziol Eksp Ter; 1991; (2):9-11. PubMed ID: 1881717.
    Abstract:
    The effect of a change in the level of the vasoactive intestinal peptide (VIP) on the behavior of rats in frontal lobectomy was studied. It was shown by means of the radioimmunological method that damage to the frontal cortex leads to a decrease of the VIP level in the cortex and increase of its content in the hypothalamus on the 9th postoperative day. Daily injection of VIP in small doses into the lateral ventricles of the brain is conducive to more rapid and complete restoration of the conditioned bilateral avoidance reflex and the animals' exploratory behavior under conditions of an "open field" as compared to that in control rats which received a physiological solution. The possibility of using VIP in experimental complex pathogenetic therapy of disturbed functions of the central nervous system is discussed.
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