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  • Title: Vitamin E dependent microRNA regulation in rat liver.
    Author: Gaedicke S, Zhang X, Schmelzer C, Lou Y, Doering F, Frank J, Rimbach G.
    Journal: FEBS Lett; 2008 Oct 15; 582(23-24):3542-6. PubMed ID: 18817776.
    Abstract:
    Dietary vitamin E (VE) is known to regulate gene expression by altering mRNA concentrations. Recently, microRNA (miRNA) have been discovered as a means of posttranscriptional gene regulation. Since the effect of VE on miRNA regulation is unknown, we fed rats for 6 months diets deficient or sufficient in VE and determined hepatic concentrations of miRNA involved in processes previously associated with VE (lipid metabolism, miRNA-122a; cancer and inflammation, miRNA-125b). VE-deficiency resulted in reduced concentrations of miRNA-122a and miRNA-125b. The findings of the present study demonstrate that differences in dietary VE may affect hepatic miRNA concentrations in vivo.
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